![]() ![]() ![]() Lack of SMGs and mucus strands disrupted mucociliary transport in EDA-KO pigs. In wild-type pigs, SMGs secrete mucus that emerges onto the airway surface as strands. Their airway surface liquid had a reduced ability to kill bacteria, consistent with SMG production of antimicrobials. EDA-KO pigs lacked SMGs throughout the airways. Therefore, we studied pigs, which have lungs like humans, and disrupted the gene for ectodysplasin ( EDA-KO), which initiates SMG development. ![]() Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. 8 Howard Hughes Medical Institute, University of Iowa, Iowa City, United States.Carver College of Medicine, University of Iowa, Iowa City, United States. 7 Department of Molecular Physiology and Biophysics, Roy J.4 Department of Biomedical Engineering, University of Iowa, Iowa City, United States.2 Division of Animal Science, University of Missouri, Columbia, United States.1 Department of Internal Medicine and Pappajohn Biomedical Institute Roy J. ![]()
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